Cell Tropism of Simian Immunodeficiency Virus in Culture Is Not Predictive of in Vivo Tropism or Pathogenesis
نویسندگان
چکیده
منابع مشابه
Cell tropism of simian immunodeficiency virus in culture is not predictive of in vivo tropism or pathogenesis.
SIVmac239/316 is a molecular clone derived from SIVmac239 that differs from the parental virus by nine amino acids in env. This virus, unlike the parental SIVmac239, is able to replicate well in alveolar macrophages in culture. We have not however, observed macrophage-associated inflammatory disease in any animal infected with SIVmac239/316. Therefore, we sought to examine the cell tropism of t...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2004
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)63261-0